Epithalon

Epithalon is the synthetic four-residue sequence Ala-Glu-Asp-Gly, distilled out of bovine pineal extract (epithalamin) by Vladimir Khavinson and his group at the St Petersburg Institute of Bioregulation and Gerontology. You will also see it written Epitalon; same molecule, two transliterations of the original Russian. Molecular weight sits at 390.35 g/mol, which is small enough that solubility and storage rarely cause headaches in the lab.

Most of the literature people quote when buying this peptide traces back to two threads: Khavinson's 2003 paper on telomerase induction in human somatic cells, and Anisimov's long-running rodent ageing work out of the Petrov Institute. Anything you read on commercial sites about lifespan, sleep cycles, or pineal rhythms ultimately points to those source papers, so it is worth reading them in the original rather than the marketing summaries.

Why labs request this specific batch

• HPLC plus mass spec on every lot. The CoA shows the actual chromatogram and the parent ion at 391.1 [M+H]+, not just a pass/fail line.
• Refund on CoA fail. If our paperwork does not match the assay you run in-house, the vial is on us. No restocking fee, no debate.
• Genuine UK and EU sourcing. Synthesised inside Europe, dispatched from England, around 90% of orders leaving within 48 hours.
• Bulk past 10 vials goes through support so we can price the run properly and reserve from the same lot, useful when you want a consistent dataset.

Research angles people order it for

The bulk of the in vitro work cited around Epithalon clusters into a few areas. Telomerase reverse transcriptase expression in somatic cell lines is the headline one, with knock-on questions about replicative senescence. There is a smaller body of work on heterochromatin decondensation in lymphocytes from older donors, plus antioxidant response and melatonin pathway modulation tied back to its pineal origin. None of that translates to a human protocol; it is all bench-side context for in vitro design.

Handling notes from the bench

• Ships as a white lyophilised powder. Bacteriostatic water reconstitutes it cleanly; saline works too.
• Reconstituted solution holds up roughly two to three weeks at 2 to 8 C in our internal stability runs. Lyophilised, frozen at minus 20 C and kept dark, the spec sheet covers 24 months.
• Aliquot before freezing if you plan repeat sampling. The peptide tolerates a freeze cycle, but glutamate and aspartate residues do not love repeated thaws.

Questions about a specific batch number, a custom quantity, or a CoA reissue can go through live chat during UK hours. The team answering is in England and reads every message.

Sold strictly for in vitro laboratory research. Not for human or veterinary use. UK 18+.