In stock
incl. VAT£35.90
In stock, ships today
Sexual Health & Libido
Kisspeptin-10
Kp-10
£24.90incl. VAT
SKU KP-10
Order before 12:00 on a working day and it ships today
Batch CoA included. HPLC purity and mass spec identity for your exact lot.
UK warehouse. Royal Mail Tracked 24, signature on delivery, 1 to 3 working days.
Plain packaging. Tamper evident, nothing on the outside naming the contents.
Stored at −20°C and shipped under inert atmosphere where the compound needs it.
Compound data
Per batch CoAPurity>99%
CAS number374675-21-5
Molecular formulaC₆₃H₈₃N₁₇O₁₄
Molecular weight1302.44 g/mol
SequenceTyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ (10 aa)
Half life<5minutes
StorageAway from light
PresentationVial
Figures above are the release specification. The certificate shipped with your vial carries the measured values for that specific lot. Email [email protected] with an order number for the raw chromatogram.
01
About this compound
Named after a chocolate, decoded in a hypothalamus
The KISS1 gene was christened in Hershey, Pennsylvania in 1996. Danny Welch and the Penn State team that identified it as a metastasis suppressor in melanoma cell lines were working a short walk from the chocolate factory, and they let the postcode do the naming. The protein they pulled out was called metastin, and for several years the biology stayed inside cancer journals.
What flipped the field was a pair of 2003 papers in the New England Journal of Medicine. Stephanie Seminara at Massachusetts General and Nicolas de Roux in Paris independently reported families with hypogonadotropic hypogonadism whose only obvious lesion was an inactivating mutation in GPR54, the orphan receptor that metastin happened to bind. The cancer peptide turned out to be the central trigger for puberty. Once that link was made the gene product was renamed kisspeptin, and Kisspeptin-10 (YNWNSFGLRF-NH2) is the 10-amino-acid C-terminal fragment that retains essentially full activity at the receptor.
What the vial contains
- Sequence: YNWNSFGLRF-NH2 (10-aa C-terminal fragment, residues 112-121 of human kisspeptin)
- Receptor: GPR54, also catalogued as KISS1R
- Gene of origin: KISS1 on chromosome 1q32
- Original alias: metastin (45-54), from the metastasis-suppressor literature
- Form supplied: lyophilised powder, sealed amber vial
- Purity check: HPLC plus mass spec, lot-specific CoA on request
The master switch upstream of GnRH
If you draw the HPG axis as the textbooks do, GnRH neurons in the hypothalamus fire pulses, the pituitary answers with LH and FSH, and the gonads do the rest. The honest version of that diagram puts one more box above GnRH: a small population of kisspeptin neurons in the arcuate nucleus and the preoptic area that decide when GnRH is allowed to pulse at all. Kp-10 is the experimental tool that lets a wet lab poke that switch directly.
Published in vitro and animal work uses Kp-10 in three broad ways. Receptor pharmacology groups characterise Gq coupling, IP3 and calcium responses, and beta-arrestin recruitment at KISS1R. Reproductive endocrinology labs track LH pulse architecture in rodent and primate models after Kp-10 infusion. A third strand, mostly out of Waljit Dhillo’s group at Imperial College London, has carried kisspeptin biology into human IVF and hypogonadism research, including kisspeptin-triggered oocyte maturation protocols that have now been through multiple clinical trials. None of that is permission to dose anything. It is the citation map a planning researcher tends to start with.
UK delivery and how the bench team works
Stock lives in our UK facility. Tracked carriers, plain outer packaging, and around nine in ten UK orders are delivered inside 48 hours. The support inbox is answered by people on UK working hours, not a ticket robot, and the same team quotes bulk pricing (ten vials or more) off the public listing if a lab is sizing up a longer study.
Every Kp-10 lot ships with an HPLC and mass spec result tied to that exact batch. If the CoA does not clear our purity threshold once it is in your hands, we refund the vial.
Bench questions worth answering up front
- Reconstitution medium? Sterile water or a mildly acidic aqueous buffer dissolves the lyophilised powder cleanly. Swirl, do not vortex. Hold the reconstituted solution at 2 to 8 degrees C and use within the working window your protocol allows.
- Half-life caveat? Kp-10 is rapidly degraded in serum in published pharmacokinetic work, which is why most in vivo studies use infusion or repeated bolus designs rather than single shots. Worth modelling before assay design.
- Kp-10 vs Kp-54? Kp-54 is the full-length mature peptide. Kp-10 is the C-terminal decapeptide and is the most studied agonist fragment, with comparable potency at KISS1R in most published binding assays.
- Dry storage? Sealed vial at -20 degrees C, protected from light and moisture, for the shelf life printed on the CoA.
Sold strictly for in vitro laboratory research. Not for human or veterinary use. UK 18+.
02
Common questions
Is it legal to buy Kisspeptin-10 in the UK?
Yes, Kisspeptin-10 is legal to buy and possess in the UK when supplied for laboratory research only, which is how we sell it. It is not a licensed medicine and is not approved for human or veterinary use. Every vial ships labelled for research use only, and it is the buyer's responsibility to handle it within that scope.
How fast is UK delivery on Kisspeptin-10?
Orders placed before the daily cut-off are dispatched the same working day from UK stock, with next-day delivery on most domestic orders via tracked Royal Mail. Because Kisspeptin-10 ships as a lyophilised powder it is stable in transit at ambient temperature, so a standard tracked service is fine. You get the tracking number by email once the label is printed.
What does the Certificate of Analysis actually prove?
The CoA confirms two separate things: identity and purity. Mass spectrometry checks the measured mass against the expected 1302.44 g/mol, which proves the vial holds Kisspeptin-10 and not a different kisspeptin variant, a known problem in this market. RP-HPLC then quantifies purity at greater than 99 percent. The CoA is batch-specific, so it matches the vial you receive.
What is Kisspeptin-10 and what does the research look at?
Kisspeptin-10 (Kp-10) is the minimal 10-amino-acid C-terminal fragment of kisspeptin that retains full agonist activity at the GPR54 receptor (KISS1R). Published in-vitro and animal research has looked at how it activates GnRH neurons in the hypothalamus and drives downstream LH and FSH release, which is why it is studied as an upstream regulator of the HPG axis.
How should Kisspeptin-10 be reconstituted and stored?
Stability is best when the sealed lyophilised vial is kept out of light, cool and dry for short periods and frozen for longer holds. In published protocols the powder is reconstituted with bacteriostatic or sterile water and the solution is then refrigerated at 2 to 8 degrees C rather than frozen. Kisspeptin-10 has a short reported half-life, so reconstituted material does not hold for long.
Do you offer Kisspeptin-10 in bulk or at trade pricing?
Yes. Per-vial pricing is shown on this page, and unit cost drops on multi-vial quantities, which is the usual route for labs running repeat assays. For larger or recurring research orders, contact us before checkout and we will quote based on volume and current batch stock. All bulk vials come from the same tested batch with the matching CoA.
Research use only. This compound is supplied for in vitro laboratory research. It is not a medicine, not a supplement, and is not licensed for human or veterinary use. Purchasers must be 18 or over and confirm research intent at checkout.
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