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from£14.90
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Nasal Peptides
Melanotan II
MT-II
£29.90incl. VAT
SKU MT2-vial
Order before 12:00 on a working day and it ships today
Batch CoA included. HPLC purity and mass spec identity for your exact lot.
UK warehouse. Royal Mail Tracked 24, signature on delivery, 1 to 3 working days.
Plain packaging. Tamper evident, nothing on the outside naming the contents.
Stored at −20°C and shipped under inert atmosphere where the compound needs it.
Compound data
Per batch CoAPurity>98%
CAS number121062-08-6
Molecular formulaC₅₀H₆₉N₁₅O₉
Molecular weight1024.18 g/mol
SequenceAc-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
Half life1-2 hours
Storage-20°C lyophilised; 2-8°C reconstituted
PresentationVial, Nasal Spray, Capsules
Figures above are the release specification. The certificate shipped with your vial carries the measured values for that specific lot. Email [email protected] with an order number for the raw chromatogram.
01
About this compound
Melanotan II, written MT-II in most of the older literature, is the cyclic lactam peptide that came out of Mac Hadley and Victor Hruby’s group at the University of Arizona in the mid-1980s. The brief at the time was unromantic: design a melanocortin agonist stable enough to survive in plasma, so it could be tested as a non-UV route to skin pigmentation and, in theory, reduce melanoma risk. The molecule they ended up with is a seven-residue ring closed through a lactam bridge between the side chains of Asp5 and Lys10. That ring is the reason MT-II behaves the way it does in receptor assays.
Why the ring matters at the bench
Native alpha-MSH is a thirteen-residue linear peptide and falls apart fast. Closing the active core into a constrained ring kept the pharmacophore in place and pushed potency up by a couple of log units against the cloned melanocortin receptors. MT-II is non-selective on purpose: it activates MC1R, MC3R, MC4R and MC5R. For receptor-pharmacology work, that breadth is the feature, not the bug. It is the standard reference agonist when a lab needs a peptide that lights up the whole melanocortin family in a single assay, before narrowing in with a more selective tool.
The lineage that gets cited everywhere
MT-II is the structural parent of PT-141 (Bremelanotide). The Palatin team took the cyclic core, cleaved the C-terminal amide back to a carboxylic acid, and got a molecule that retained MC3R and MC4R activity while dropping the pigment-driving MC1R response. If you are running a comparative receptor study or writing a chapter on melanocortin medicinal chemistry, the MT-II to Bremelanotide arc is the worked example most reviews use. Worth having the parent compound on the bench rather than relying on the metabolite alone.
Provenance of the powder
- Lyophilised MT-II at 10 mg per glass vial, sealed under inert atmosphere
- Purity 98 percent or higher by reverse-phase HPLC, identity confirmed by ESI-MS
- Synthesised at a UK or EU contract peptide house we have audited in person
- Lot-specific Certificate of Analysis with the actual chromatogram and MS trace, not a generic template
We do not list MT-II from unverified Asian re-packers. The recurring failure mode on this peptide is not gross purity, it is acetate counter-ion drift and trace TFA carry-over, both of which quietly skew MC1R EC50 numbers in functional assays. If a batch you receive does not match its CoA, refund. That rule applies across the catalogue.
Holding it stable
Lyophilised MT-II is tolerant for shipping but should move to minus 20 C on arrival for any storage past a few weeks. Once reconstituted in bacteriostatic water or sterile saline, refrigerate and treat the solution as short-lived for assay work where receptor data has to stand up to review. The acetate salt is mildly hygroscopic, so cap tightly between uses.
Stock is held in the UK and roughly nine in ten UK orders are with the courier inside 48 hours. If you need ten vials or more for a longer protocol, message support rather than clicking add-to-cart ten times. Bulk pricing is set by a quick conversation, not a calculator. Live chat is staffed during UK hours by people who actually handle the orders, so questions about reconstitution volume or a CoA peak get a real answer.
Sold strictly for in vitro laboratory research. Not for human or veterinary use. UK 18+.
02
Common questions
Is it legal to buy Melanotan II in the UK?
Yes, Melanotan II can be bought and sold in the UK as a research chemical. It is not a controlled substance under the Misuse of Drugs Act 1971. It is not a licensed medicine, however, and is not approved for human use in any form, so it is supplied strictly for in-vitro and laboratory research. The MHRA has previously acted against sellers making medicinal claims, not against the compound itself.
How fast is UK delivery, and how is it shipped?
Orders placed on a working day are dispatched the same day from our UK stock, so most researchers receive tracked delivery next working day. Each vial ships as a lyophilised powder, which is stable at room temperature for the short transit window. Once it reaches you, move it to a freezer at -20C until you are ready to reconstitute it.
What does the Certificate of Analysis actually prove?
The CoA reports two independent tests on the specific batch you receive. HPLC measures chromatographic purity, confirming the peptide is above 98 percent and showing what the rest of the sample is. Mass spectrometry confirms identity by matching the measured mass to the expected 1024.18 g/mol. Together they tell you the vial holds the labelled sequence at the stated purity, not a near analogue or a degraded lot.
What is Melanotan II and what does the research look at?
Melanotan II is a synthetic cyclic heptapeptide and a non-selective melanocortin receptor agonist, active at MC1R, MC3R, MC4R and MC5R. It was developed from alpha-MSH at the University of Arizona in the 1980s by the Hruby and Hadley groups. Published in-vitro and animal research has examined its role in melanocortin signalling, pigmentation pathways and energy balance. It is also the structural parent of PT-141 (bremelanotide).
What is the sequence, and how should it be reconstituted and stored?
The sequence is Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2, a six-residue ring closed by an Asp-Lys lactam bridge with an N-terminal norleucine. Reconstitute the lyophilised powder with bacteriostatic or sterile water, adding it down the vial wall and swirling rather than shaking. Lyophilised, it keeps at -20C for up to two years; once reconstituted, hold it at 2-8C and use within roughly two weeks, where it typically stays near 90 percent purity.
How much does Melanotan II cost, and do you sell in bulk?
The price per vial is shown at the top of this page in GBP. On the wider market, verifiable-CoA Melanotan II tends to sit well above the cheap overseas-sourced material, because batch HPLC and MS testing cost money to run. We hold UK stock rather than drop-shipping, so what you order is what we have tested. For larger research quantities, contact us before ordering and we will quote on volume.
Research use only. This compound is supplied for in vitro laboratory research. It is not a medicine, not a supplement, and is not licensed for human or veterinary use. Purchasers must be 18 or over and confirm research intent at checkout.
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